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Feeding Your Brain: Nutritional Therapy for Depression

Depression is a complex mental health condition with various contributing factors, and recent research suggests that Nutritional Therapy can be an important tool in helping to alleviate symptoms.

 In this blog post, we will explore the significance of particular nutrients in addressing depression and how incorporating them into a holistic approach, along with lifestyle changes and psychological support, can help to enhance mental well-being.

The Role of Fats in Brain Health

The human brain is predominantly composed of fat, constituting approximately 60% of its dry weight in the form of fatty acids. Within this complex organ, neurons, the fundamental building blocks of the nervous system, heavily rely on adequate levels of omega-3 fatty acids to function optimally.

The balance of these essential fatty acids is pivotal for maintaining mental equilibrium. Their deficiency has been correlated with a spectrum of mental health issues, including inflammation, suicidality, depression, aggression, anxiety, gastrointestinal problems, and autoimmunity.

Low Dietary Intake of Omega-3 and its Consequences

Scientific investigation highlights the impact of a deficient intake of omega-3 fatty acids on mental health. Studies reveal an alarming 25% greater risk of death from suicide, a 2.6-fold increased risk of depression, and a 1.5-fold elevated risk of suicidal thoughts associated with insufficient omega-3 levels.

What's more, individuals experiencing depression and anxiety often exhibit an imbalanced ratio of omega-6 to omega-3 fatty acids. To counteract this, a recommended daily intake of at least 3 grams of omega-3 fatty acids becomes a crucial step in fostering mental well-being.

It's worth noting that the transformation of the cellular fat balance is a gradual process, requiring approximately 12 weeks of sustained effort. Thus, consistency in incorporating omega-3-rich foods or supplements into one's diet emerges as a cornerstone for realising the potential benefits.

MTHFR Variants and Depression

Certain genetic variations, such as MTHFR variants, have emerged as key players. These variations are linked not only to depression but also to conditions like ADHD, addictions, and OCD.

Acknowledging one's genetic predispositions becomes a compass for tailoring nutritional interventions to address specific needs, offering a more personalised approach to mental well-being.

MTHFR, or methylenetetrahydrofolate reductase, is an enzyme involved in the conversion of folate (vitamin B9) into its active form, methylfolate. This active form is crucial for a process called methylation, which is involved in numerous biochemical reactions in the body, including the synthesis of neurotransmitters like serotonin, dopamine, and norepinephrine.

Methylation and Neurotransmitters:

  • Methylation is a key process for the production and regulation of neurotransmitters in the brain. Neurotransmitters play a critical role in mood regulation and emotional well-being.

  • MTHFR variants can affect the efficiency of methylation, potentially leading to imbalances in neurotransmitter levels. Reduced methylation capacity may contribute to the development or exacerbation of mood disorders, including depression.

Folate Deficiency and Depression:

  • MTHFR variants are associated with a decreased ability to convert folate into its active form. This impaired conversion can result in lower levels of active folate available for methylation processes.

  • Folate deficiency has been linked to an increased risk of depression. Adequate folate levels are essential for the synthesis of neurotransmitters and the regulation of homocysteine, an amino acid that, when elevated, is associated with a higher risk of depression.

  • However, we must also consider that in Dr Walsh's research, supplementing undermethylators with folate may worsen depression symptoms by reducing serotonin levels. This highlights the importance of working with a healthcare practitioner to understand your unique biochemistry.

Impact on Homocysteine Levels:

  • MTHFR variants are implicated in elevated homocysteine levels. High homocysteine levels have been associated with an increased risk of various cardiovascular and neurological conditions, including depression.

  • Elevated homocysteine levels may contribute to inflammation and oxidative stress in the brain, further impacting mental health.

Comorbidity with Other Conditions:

  • Beyond depression, MTHFR variants have been linked to a range of neuropsychiatric conditions, including ADHD (Attention Deficit Hyperactivity Disorder), addictions, and OCD (Obsessive-Compulsive Disorder).

  • The intricate web of genetic factors interacting with environmental influences makes individuals with MTHFR variants susceptible to a diverse array of mental health challenges.

Personalised Approaches:

  • Understanding one's MTHFR status allows for a more personalised approach to healthcare. Individuals with MTHFR variants may benefit from targeted nutritional interventions, such as supplementation with methylfolate, to bypass the impaired enzymatic conversion.

  • This personalised approach aligns with the concept of precision medicine, tailoring treatments based on an individual's unique genetic makeup for better outcomes.

Lifestyle Factors and MTHFR:

  • Lifestyle factors, including diet, can modulate the impact of MTHFR variants. A diet rich in B vitamins, magnesium, and other nutrients supportive of methylation processes may help mitigate the effects of MTHFR variants on mental health.

  • Avoidance of certain environmental factors, such as exposure to toxins, is also crucial for individuals with MTHFR variants, as these factors can further stress the methylation pathways.

The Impact of Zinc Deficiency

Zinc, a mineral with far-reaching implications for physiological processes, is another nutrient that takes centre stage in the narrative of depression.

Deficiencies in this essential element have been correlated with depressive states. Factors contributing to zinc deficiency include intensive exercise, exposure to toxins, poor nutrition, and an increased demand for zinc during periods of puberty, adolescence, and stress.

Also significant is that individuals with low zinc levels may experience a diminished efficacy of antidepressant medications, highlighting the importance of complementing allopathic medicine with Nutritional Therapy.

The Dopaminergic System and Depression

Venturing into the neurochemical landscape, dopamine emerges as another key player in depression. Commonly associated with motivation and reward, dopamine levels are impacted by medications such as SSRIs, with specific effects noted in the firing rate and burst activity of dopaminergic neurons. Escitalopram, a commonly prescribed SSRI, is known to exemplify this influence.

Addressing Depression through Nutrients and Amino Acids

Certain supplements containing amino acid precursors to dopamine, such as L-tyrosine and L-dopa may, in some individuals, offer potential avenues for promoting a healthier dopaminergic system.

Complementary supplements like Rhodiola, grape seed, and green tea contribute to maintaining dopamine in the synapse for extended periods, potentially alleviating symptoms linked to low dopamine levels.

*It is important to note that depression can have various different underlying biochemical drivers, so what may be helpful for one person, may not be suitable for another. Getting assessed by a healthcare practitioner is essential for creating a personalised plan.

Holistic Approach to Mental Well-being

Beyond nutritional interventions, a holistic approach to mental well-being incorporates essential lifestyle and psychological factors.

Adequate sleep, a cornerstone of overall health, and well-studied practices such as mindfulness and yoga can help to manage stress and elevate mood. These practices serve as integral components in the broader strategy for nurturing mental resilience.

Finally, reaching out for psychological support is often an essential piece of the puzzle for individuals experiencing depression. These practices serve as integral components in the broader strategy for nurturing mental resilience.

In the evolving landscape of mental health, nutritional therapy emerges as a promising frontier, directing attention to essential fatty acids, zinc, and dopamine. The integration of these nutritional elements into a holistic framework, complemented by lifestyle modifications, paints a comprehensive portrait of mental well-being.

As with any guidance related to health, it is imperative to consult a healthcare professional, ensuring a tailored and informed approach to mental wellness.

Next Steps

Hi I'm Molly, I'm a UK-based Nutritional Therapist (MSc, DipION, mBANT, CNHC) serving my community in Harpenden and online.

On my website, you'll discover the benefits of nutritional therapy for women struggling with health challenges, from autoimmunity to hormone issues, and Paediatric health. Want to understand more about nutrition for autoimmune diseases? Download my free recipe book and discover 12 Nutritionist-Certified Recipes to Help Alleviate the Symptoms of Autoimmunity & Chronic Illness.

If you feel like Nutritional Therapy could be the right step for you, and you want to find out more, please book a complimentary call, in which we will discuss your goals, any symptoms that you would like to address, and relevant medical history that you think I should know about. Together, we will decide if this is the right step for you.


  1. Psychiatry Redefined: Nutritional Augmentation for Antidepressant Use Lecture.


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